(±)-trans-1,2-Cyclohexanediamine-Based Bis(NHC) Ligand for Cu-Catalyzed Asymmetric Conjugate Addition Reaction

Peptidic Amidomonophosphane Ligand for Copper-Catalyzed Asymmetric Conjugate Addition of Diorganozincs to Cycloalkenones

Cu(II)-catalyzed asymmetric boron conjugate addition to α,β-unsaturated imines in water.

Enantioselective conjugate addition of bis(pinacolato)diboron to α,β-unsaturated imines proceeds smoothly in water in the presence of a chiral copper(II) complex consisting of Cu(OAc)2 and chiral 2,2'-bipyridine. The corresponding β-boryl imines, which were oxidized to β-hydroxy imines, further leading to γ-amino alcohols, were obtained in high yields and high enantioselectivities.

Cu-catalyzed stereoselective conjugate addition of arylboronic acids to alkynoates.

The CuOAc-catalyzed reaction of internal alkynoates with arylboronic acids proceeded under mild conditions to yield trisubstituted cinnamates stereoselectively.

Regiodivergent 1,4 versus 1,6 asymmetric copper-catalyzed conjugate addition.

Cu (II)-catalyzed asymmetric henry reaction with a novel C1-symmetric aminopinane-derived ligand.

A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(-)-isopinocampheylamine and 1-methyl-2-imidazolecarboxaldehyde. In combination with Cu(OAc)2H2O, this new ligand promote the reaction between nitromethane and aliphatic aldehydes with high yields (up to 97%) and moderate enantioselectivities (up to 67% ee). The reactions with benzalde...